Article
Correlation of epidermal growth factor receptor mutation status in plasma and tissue samples of patients with non-small cell lung cancer.
Journal of cancer research and therapeutics - 1 Jan 2000
Roh Mee-Sook, Yoon Neul-Bom, Lee Seul, Kang Bo-Hyoung, Um Soo-Jung, Lee Dong-Hyun, Son Choonhee
Abstract excerpt
BACKGROUND: Somatic mutations of the gene encoding epidermal growth factor receptor (EGFR) are detected in approximately 30%-50% of patients with non-small cell lung cancers (NSCLC), so detection of EGFR mutation is the pivotal step of treatment in patients with advanced NSCLC. However, difficulty in obtaining sufficient tissue and bias from the heterogeneity of the tumor samples are the major obstacles. Although...
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