CONCORDANCE: A real-world evidence study to evaluate the concordance of detecting epidermal growth factor receptor (EGFR) mutation by circulating tumor DNA* versus tissue biopsy in patients with metastatic non-small cell lung cancer.

doi:10.4103/ijc.ijc_438_21

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CONCORDANCE: A real-world evidence study to evaluate the concordance of detecting epidermal growth factor receptor (EGFR) mutation by circulating tumor DNA* versus tissue biopsy in patients with metastatic non-small cell lung cancer.

Indian journal of cancer - 1 Mar 2022

Prabhash Kumar, Biswas Bivas, Khurana Sachin, Batra Ullas, Biswas Ghanashyam, Advani Suresh Hariram, Mohapatra Prabrajya N, Rajappa Senthil, Sharma Ajay, Patil Shekhar, Dattatreya Palanki Satya, Roy Rakesh, Almel Sachin, Goyal Gautam, Warrier Narayanankutty

Abstract excerpt

Background: Molecular tissue testing in non-small cell lung cancer (NSCLC) is done for the assessment of epidermal growth factor receptor (EGFR) mutation. EGFR mutation status is the basis for deciding the targeted treatment option for patients with metastatic NSCLC. The nonavailability of tissue samples and contraindications for biopsy pose a significant challenge. Hence, circulating tumor DNA (ctDNA) by liquid...

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PMID: 35343188
DOI: 10.4103/ijc.ijc_438_21

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