Article
Utility of Liquid Biopsy by Improved PNA-LNA PCR Clamp Method for Detecting EGFR Mutation at Initial Diagnosis of Non-Small-Cell Lung Cancer: Observational Study of 190 Consecutive Cases in Clinical Practice.
Clinical lung cancer - 1 Mar 2018
Ito Kentaro, Suzuki Yuta, Saiki Haruko, Sakaguchi Tadashi, Hayashi Kosuke, Nishii Yoichi, Watanabe Fumiaki, Hataji Osamu
Abstract excerpt
BACKGROUND: The clinical benefit of liquid biopsy for unselected patients at initial diagnosis has thus far been unclear. We aimed to evaluate the utility of liquid biopsy at initial diagnosis, as well as the efficacy of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) based on liquid biopsy results in clinical practice, using the improved peptide nucleic acid-locked nucleic acid (PNA-LNA)...
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