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Comparison of epidermal growth factor receptor mutation statuses in tissue and plasma in stage I-IV non-small cell lung cancer patients.

Respiration; international review of thoracic diseases - 1 Jan 2013

Zhao Xiao, Han Ru-Bing, Zhao Jing, Wang Jun, Yang Fan, Zhong Wei, Zhang Li, Li Long-Yun, Wang Meng-Zhao

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor (EGFR) mutations play essential roles in the treatment of non-small cell lung cancer (NSCLC) patients using EGFR tyrosine kinase inhibitors. Detection of EGFR mutations in blood cell-free DNA (cfDNA) seems promising. However, the mutation status in the plasma/serum is not always consistent with that in the tissues. OBJECTIVES: The aims of this study were to compare the...

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Aged, 80 and over
Carcinoma, Non-Small-Cell Lung
DNA Mutational Analysis
ErbB Receptors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22797485
DOI: 10.1159/000338790

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EGFR

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