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Dynamic plasma EGFR mutation status as a predictor of EGFR-TKI efficacy in patients with EGFR-mutant lung adenocarcinoma.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2015

Tseng Jeng-Sen, Yang Tsung-Ying, Tsai Chi-Ren, Chen Kun-Chieh, Hsu Kuo-Hsuan, Tsai Meen-Hsin, Yu Sung-Liang, Su Kang-Yi, Chen Jeremy J W, Chang Gee-Chen

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor (EGFR) mutation status in lung cancer can effectively predict EGFR-tyrosine kinase inhibitor (TKI) efficacy. We evaluated the role of dynamic plasma cell-free DNA EGFR mutation status in outcome prediction. METHODS: Advanced lung adenocarcinoma patients were enrolled and prospectively observed for outcomes of EGFR-TKI treatment. Peptide nucleic acid-zip nucleic acid...

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Adenocarcinoma of Lung
Anilides
Disease-Free Survival
DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Staging

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PMID: 25514801
DOI: 10.1097/JTO.0000000000000443

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EGFR

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