Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas.

doi:10.1158/0008-5472.CAN-20-0078

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Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas.

Cancer research - 15 Oct 2020

Lenkiewicz Elizabeth, Malasi Smriti, Hogenson Tara L, Flores Luis F, Barham Whitney, Phillips William J, Roesler Alexander S, Chambers Kendall R, Rajbhandari Nirakar, Hayashi Akimasa, Antal Corina E, Downes Michael, Grandgenett Paul M, Hollingsworth Michael A, Cridebring Derek, Xiong Yuning, Lee Jeong-Heon, Ye Zhenqing, Yan Huihuang, Hernandez Matthew C, Leiting Jennifer L, Evans Ronald M, Ordog Tamas, Truty Mark J, Borad Mitesh J, Reya Tannishtha, Von Hoff Daniel D, Fernandez-Zapico Martin E, Barrett Michael T

Abstract excerpt

Adenosquamous cancer of the pancreas (ASCP) is a subtype of pancreatic cancer that has a worse prognosis and greater metastatic potential than the more common pancreatic ductal adenocarcinoma (PDAC) subtype. To distinguish the genomic landscape of ASCP and identify actionable targets for this lethal cancer, we applied DNA content flow cytometry to a series of 15 tumor samples including five patient-derived...

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Identifiers

PMID: 32928922
DOI: 10.1158/0008-5472.CAN-20-0078
PMCID: PMC7906529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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