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Histone H4 LRS mutations can attenuate UV mutagenesis without affecting PCNA ubiquitination or sumoylation.

DNA repair - 1 Nov 2020

Selvam Kathiresan, Rahman Sheikh Arafatur, Forrester Derek, Bao Adam, Lieu Michael, Li Shisheng

Abstract excerpt

UV is a significant environmental agent that damages DNA. Translesion synthesis (TLS) is a DNA damage tolerance pathway that utilizes specialized DNA polymerases to replicate through the damaged DNA, often leading to mutagenesis. In eukaryotic cells, genomic DNA is organized into chromatin that is composed of nucleosomes. To date, if and/or how TLS is regulated by a specific nucleosome feature has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32927239
DOI: 10.1016/j.dnarep.2020.102959

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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