Article
Genetics and Omics Analysis of Autoimmune Skin Blistering Diseases.
Frontiers in immunology - 1 Jan 2019
Olbrich Michael, Künstner Axel, Witte Mareike, Busch Hauke, Fähnrich Anke
Abstract excerpt
Autoimmune blistering diseases (AIBDs) of the skin are characterized by autoantibodies against different intra-/extracellular structures within the epidermis and at the basement membrane zone (BMZ). Binding of the antibodies to their target antigen leads to inflammation at the respective binding site and degradation of these structures, resulting in the separation of the affected skin layers. Clinically,...
Topics
- Alleles
- Autoantigens
- Autoimmune Diseases
- Genetic Predisposition to Disease
- Genomics
- HLA-DQ Antigens
- HLA-DR Antigens
- Humans
- Risk Factors
- Skin Diseases, Vesiculobullous