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Article

DNA methylation of hypertension-related genes and effect of riboflavin supplementation in adults stratified by genotype for the MTHFR C677T polymorphism.

International journal of cardiology - 1 Jan 2021

Amenyah Sophia D, Ward Mary, McMahon Amy, Deane Jennifer, McNulty Helene, Hughes Catherine, Strain J J, Horigan Geraldine, Purvis John, Walsh Colum P, Lees-Murdock Diane J

Abstract excerpt

BACKGROUND: The interaction between genetic, epigenetic and environmental factors plays an important role in the aetiology of hypertension. GWAS and observational studies link the C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) with hypertension, while riboflavin, the MTHFR cofactor, has been shown to reduce blood pressure and global DNA methylation in homozygous (TT genotype) individuals. It is...

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Identifiers

PMID: 32920065
DOI: 10.1016/j.ijcard.2020.09.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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