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Article

Impact of the MTHFR C677T polymorphism on blood pressure and related central haemodynamic parameters in healthy adults.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association - 1 Aug 2022

Rooney Martina, Hughes Catherine F, Strain J J, Clements Michelle, McNulty Helene, Ward Mary

Abstract excerpt

BACKGROUND: The C677T polymorphism in the gene-encoding methylenetetrahydrofolate reductase (MTHFR) is associated with an increased risk of hypertension and cardiovascular disease. Riboflavin, the MTHFR cofactor, is an important modulator of blood pressure (BP) in adults homozygous for this polymorphism (TT genotype). The effect of this genetic variant on BP and related central haemodynamic parameters in healthy...

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Identifiers

PMID: 35821207
DOI: 10.1111/jhn.13061
PMCID: PMC9541256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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