Article
Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines.
The pharmacogenomics journal - 1 Mar 2017
Chhibber A, French C E, Yee S W, Gamazon E R, Theusch E, Qin X, Webb A, Papp A C, Wang A, Simmons C Q, Konkashbaev A, Chaudhry A S, Mitchel K, Stryke D, Ferrin T E, Weiss S T, Kroetz D L, Sadee W, Nickerson D A, Krauss R M, George A L, Schuetz E G, Medina M W, Cox N J, Scherer S E, Giacomini K M, Brenner S E
Abstract excerpt
Variation in the expression level and activity of genes involved in drug disposition and action ('pharmacogenes') can affect drug response and toxicity, especially when in tissues of pharmacological importance. Previous studies have relied primarily on microarrays to understand gene expression differences, or have focused on a single tissue or small number of samples. The goal of this study was to use...
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