Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation.

Molecular and cellular biology - 1 Jan 2006

Tzatsos Alexandros, Kandror Konstantin V

Abstract excerpt

Nutritional excess and/or obesity represent well-known predisposition factors for the development of non-insulin-dependent diabetes mellitus (NIDDM). However, molecular links between obesity and NIDDM are only beginning to emerge. Here, we demonstrate that nutrients suppress phosphatidylinositol 3 (PI3)-kinase/Akt signaling via Raptor-dependent mTOR (mammalian target of rapamycin)-mediated phosphorylation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Insulin Receptor Substrate Proteins
Share to Leucine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Monomeric GTP-Binding Proteins

Share to Neuropeptides

Share to Proto-Oncogene Proteins c-akt

Share to Serine

Share to Sirolimus

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 16354680
DOI: 10.1128/MCB.26.1.63-76.2006
PMCID: PMC1317643

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation.PMID 16354680Read ↗

GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling.Semantic proximity Read ↗

AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.Semantic proximity Read ↗

Nutrient regulation of mTORC1 at a glanceSemantic proximity Read ↗

Differential expression of mTOR related molecules in the placenta from gestational diabetes mellitus (GDM), intrauterine growth restriction (IUGR) and preeclampsia patientsSemantic proximity Read ↗

Dietary protein governs the role of insulin signaling in the postprandial regulation of hepatic mTORC1Semantic proximity Read ↗

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.Semantic proximity Read ↗

Novel torin1-sensitive phosphorylation sites on the metabolic regulator AMPK revealed by label-free mass spectrometrySemantic proximity Read ↗

Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase.Semantic proximity Read ↗

mTOR and the control of whole body metabolism.Semantic proximity Read ↗

Impairment of the IR-IRS-PI3K-AKT signaling pathway in Insulin Resistance: New Insights into Insulin Resistance MechanismsSemantic proximity Read ↗

mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and agingSemantic proximity Read ↗

mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.