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Article

Both germ line and somatic genetics of the p53 pathway affect ovarian cancer incidence and survival.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2008

Bartel Frank, Jung Juliane, Böhnke Anja, Gradhand Elise, Zeng Katharina, Thomssen Christoph, Hauptmann Steffen

Abstract excerpt

PURPOSE: Although p53 is one of the most studied genes/proteins in ovarian carcinomas, the predictive value of p53 alterations is still ambiguous. EXPERIMENTAL DESIGN: We performed analyses of the TP53 mutational status and its protein expression using immunohistochemistry. Moreover, the single nucleotide polymorphism SNP309 in the P2 promoter of the MDM2 gene was investigated. We correlated the results with age...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18172257
DOI: 10.1158/1078-0432.CCR-07-1192

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Both germ line and somatic genetics of the p53 pathway affect ovarian cancer incidence and survival.PMID 18172257Read ↗

[Both somatic and germline genetics of the TP53-pathway influence ovarian cancer incidence and survival].Semantic proximity Read ↗

MDM2 SNP309 modifies the prognostic significance of the p53 mutational status in patients with ovarian cancer.Semantic proximity Read ↗

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