Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Both germ line and somatic genetics of the p53 pathway affect ovarian cancer incidence and survival.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2008

Bartel Frank, Jung Juliane, Böhnke Anja, Gradhand Elise, Zeng Katharina, Thomssen Christoph, Hauptmann Steffen

Abstract excerpt

PURPOSE: Although p53 is one of the most studied genes/proteins in ovarian carcinomas, the predictive value of p53 alterations is still ambiguous. EXPERIMENTAL DESIGN: We performed analyses of the TP53 mutational status and its protein expression using immunohistochemistry. Moreover, the single n...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Drug Resistance, Neoplasm
Share to Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kaplan-Meier Estimate

Share to Ovarian Neoplasms

Share to Proto-Oncogene Proteins c-mdm2

Share to Survival Analysis

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 18172257
DOI: 10.1158/1078-0432.CCR-07-1192

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18172257-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Both germ line and somatic genetics of the p53 pathway affect ovarian cancer incidence and survival.PMID 18172257Read ↗

[Both somatic and germline genetics of the TP53-pathway influence ovarian cancer incidence and survival].Semantic proximity Read ↗

MDM2 SNP309 modifies the prognostic significance of the p53 mutational status in patients with ovarian cancer.Semantic proximity Read ↗

Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers.Semantic proximity Read ↗

MDM2SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk.Semantic proximity Read ↗

Association of p73 and MDM2 polymorphisms with the risk of epithelial ovarian cancer in Chinese women.Semantic proximity Read ↗

Mdm2 Snp309 G allele displays high frequency and inverse correlation with somatic P53 mutations in hepatocellular carcinoma.Semantic proximity Read ↗

Correlation of p53 mutations with resistance to platinum-based chemotherapy and shortened survival in ovarian cancer.Semantic proximity Read ↗

A single nucleotide polymorphism in the p53 pathway interacts with gender, environmental stresses and tumor genetics to influence cancer in humans.Semantic proximity Read ↗

Prognostic significance of p53 mutation and p53 overexpression in advanced epithelial ovarian cancer: a Gynecologic Oncology Group Study.Semantic proximity Read ↗

MDM2 SNP309 accelerates breast and ovarian carcinogenesis in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent.Semantic proximity Read ↗

Common polymorphisms in TP53 and MDM2 and the relationship to TP53 mutations and clinical outcomes in women with ovarian and peritoneal carcinomas.Semantic proximity Read ↗

p53 signaling pathway polymorphisms, cancer risk and tumor phenotype in TP53 R337H mutation carriers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.