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Article

An engineered pancreatic cancer model with intra-tumoral heterogeneity of driver mutations.

Lab on a chip - 21 Oct 2020

Moon Hye-Ran, Ozcelikkale Altug, Yang Yi, Elzey Bennett D, Konieczny Stephen F, Han Bumsoo

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a complex disease with significant intra-tumoral heterogeneity (ITH). Currently, no reliable PDAC tumor model is available that can present ITH profiles in a controlled manner. We develop an in vitro microfluidic tumor model mimicking the heterogeneous accumulation of key driver mutations of human PDAC using cancer cells derived from genetically engineered mouse models....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32909573
DOI: 10.1039/d0lc00707b
PMCID: PMC9178523

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