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Article

The transcriptional repressor Bcl6 promotes pre-TCR-induced thymocyte differentiation and attenuates Notch1 activation.

Development (Cambridge, England) - 7 Oct 2020

Solanki Anisha, Yánez Diana C, Lau Ching-In, Rowell Jasmine, Barbarulo Alessandro, Ross Susan, Sahni Hemant, Crompton Tessa

Abstract excerpt

Pre-T-cell receptor (TCR) signal transduction is required for developing thymocytes to differentiate from CD4-CD8- double-negative (DN) cell to CD4+CD8+ double-positive (DP) cell. Notch signalling is required for T-cell fate specification and must be maintained throughout β-selection, but inappropriate Notch activation in DN4 and DP cells is oncogenic. Here, we show that pre-TCR signalling leads to increased...

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Identifiers

PMID: 32907850
DOI: 10.1242/dev.192203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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