Article
Biogenesis of circular RNAs and their role in cellular and molecular phenotypes of neurological disorders.
Seminars in cell & developmental biology - 1 Jun 2021
Guerra B S, Lima J, Araujo Bhs, Torres L B, Santos Jcc, Machado Djs, Cunha Ebb, Serrato J A, de Souza J S, Martins J V, Scalabrin E E, Herai R H
Abstract excerpt
Circular RNA (circRNA) is an unusual class of RNA-like structures composed by exonic and/or intronic sequences that are regulated by the backsplicing mechanism and by the spliceosome-mediated machinery. These circular transcripts tend to accumulate during aging in several human tissues, especially in the mammalian brain, and their expression is correlated with the occurrence of several human pathologies,...
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