Patterns of Resistance-Associated Substitutions in Patients With Chronic HCV Infection Following Treatment With Direct-Acting Antivirals.

doi:10.1053/j.gastro.2017.11.007

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Article

Patterns of Resistance-Associated Substitutions in Patients With Chronic HCV Infection Following Treatment With Direct-Acting Antivirals.

Gastroenterology - 1 Mar 2018

Dietz Julia, Susser Simone, Vermehren Johannes, Peiffer Kai-Henrik, Grammatikos Georgios, Berger Annemarie, Ferenci Peter, Buti Maria, Müllhaupt Beat, Hunyady Bela, Hinrichsen Holger, Mauss Stefan, Petersen Jörg, Buggisch Peter, Felten Gisela, Hüppe Dietrich, Knecht Gaby, Lutz Thomas, Schott Eckart, Berg Christoph, Spengler Ulrich, von Hahn Thomas, Berg Thomas, Zeuzem Stefan, Sarrazin Christoph

Abstract excerpt

BACKGROUND & AIMS: Little is known about substitutions that mediate resistance of hepatitis C virus (HCV) to direct-acting antivirals (DAAs), due to the small number of patients with treatment failure in approval studies. It is important to identify resistance patterns to select effective salvage treatments. METHODS: We performed a comprehensive analysis for resistance-associated substitutions (RASs) in HCV genes...

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PMID: 29146520
DOI: 10.1053/j.gastro.2017.11.007

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