Prevalence of Drug Resistance Associated Substitutions in Persons With Chronic Hepatitis C Infection and Virological Failure Following Initial or Re-treatment With Pan-genotypic Direct-Acting Antivirals: A Systematic Review and Meta-analysis.

doi:10.1093/cid/ciae431

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Prevalence of Drug Resistance Associated Substitutions in Persons With Chronic Hepatitis C Infection and Virological Failure Following Initial or Re-treatment With Pan-genotypic Direct-Acting Antivirals: A Systematic Review and Meta-analysis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 17 Dec 2024

Inzaule Seth, Easterbrook Philippa, Latona Ashley, Ford Nathan P, Irving William, Matthews Philippa C, Vitoria Marco, Duncombe Chris, Giron Amalia, McCluskey Suzanne, Lesi Olufunmilayo, Tchamgoue Serge, Halford Rachel, Adda Danjuma, Thomson Emma, Dusheiko Geoff, Jordan Michael R

Abstract excerpt

BACKGROUND: The advent of short-course, curative treatment with direct-acting antivirals (DAA) has given promise for the global elimination of hepatitis C virus (HCV) infections by 2030. Virological failure occurs in 2%-12% of persons receiving curative DAA treatment and may be presaged by pre-existing polymorphisms or result from selection of drug resistant variants during therapy. METHODS: We conducted a...

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PMID: 39361017
DOI: 10.1093/cid/ciae431
PMCID: PMC11650865

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