Amino Acid Substitutions Associated with Treatment Failure for Hepatitis C Virus Infection.

doi:10.1128/JCM.01985-20

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Article

Amino Acid Substitutions Associated with Treatment Failure for Hepatitis C Virus Infection.

Journal of clinical microbiology - 18 Nov 2020

Soria María Eugenia, García-Crespo Carlos, Martínez-González Brenda, Vázquez-Sirvent Lucía, Lobo-Vega Rebeca, de Ávila Ana Isabel, Gallego Isabel, Chen Qian, García-Cehic Damir, Llorens-Revull Meritxell, Briones Carlos, Gómez Jordi, Ferrer-Orta Cristina, Verdaguer Nuria, Gregori Josep, Rodríguez-Frías Francisco, Buti María, Esteban Juan Ignacio, Domingo Esteban, Quer Josep, Perales Celia

Abstract excerpt

Despite the high virological response rates achieved with current directly acting antiviral agents (DAAs) against hepatitis C virus (HCV), around 2% to 5% of treated patients do not achieve a sustained viral response. The identification of amino acid substitutions associated with treatment failure requires analytical designs, such as subtype-specific ultradeep sequencing (UDS) methods, for HCV characterization...

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Identifiers

PMID: 32999010
DOI: 10.1128/JCM.01985-20
PMCID: PMC7685896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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