Article
World-wide Prevalence of Substitutions in HCV Genome Associated With Resistance to Direct-Acting Antiviral Agents.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Sept 2021
Liu Zhenqiu, Mao Xianhua, Wu Jiaqi, Yu Kangkang, Yang Qin, Suo Chen, Lu Ming, Jin Li, Zhang Tiejun, Chen Xingdong
Abstract excerpt
BACKGROUND & AIMS: The efficacy of direct-acting antiviral agents against hepatitis C virus (HCV) infection can be compromised by substitutions in the HCV genome that occur before treatment (resistance-associated substitutions [RASs]). We performed a meta-analysis to determine the prevalence of RASs and their effects. METHODS: We searched publication databases for studies of HCV RNA substitutions that mediate...
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