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Article

Heart rate dynamics in monoamine oxidase-A- and -B-deficient mice.

American journal of physiology. Heart and circulatory physiology - 1 May 2002

Holschneider D P, Scremin O U, Chialvo D R, Chen K, Shih J C

Abstract excerpt

Heart rate (HR) dynamics were investigated in mice deficient in monoamine oxidase A and B, whose phenotype includes elevated tissue levels of norepinephrine, serotonin, dopamine, and phenylethylamine. In their home cages, spectral analysis of R-R intervals revealed more pronounced fluctuations at all frequencies in the mutants compared with wild-type controls, with a particular enhancement at 1-4 Hz. No...

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Identifiers

PMID: 11959640
DOI: 10.1152/ajpheart.00600.2001
PMCID: PMC4075429

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Source receipt: pubmed, retrieved 7 Sept 2026.

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