Article
Mutation of regulatory phosphorylation sites in PFKFB2 worsens renal fibrosis.
Scientific reports - 3 Sept 2020
Lee Mardiana, Harley Geoff, Katerelos Marina, Gleich Kurt, Sullivan Mitchell A, Laskowski Adrienne, Coughlan Melinda, Fraser Scott A, Mount Peter F, Power David A
Abstract excerpt
Fatty acid oxidation is the major energy pathway used by the kidney, although glycolysis becomes more important in the low oxygen environment of the medulla. Fatty acid oxidation appears to be reduced in renal fibrosis, and drugs that reverse this improve fibrosis. Expression of glycolytic genes is more variable, but some studies have shown that inhibiting glycolysis reduces renal fibrosis. To address the role of...
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