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Overexpression of PFKFB3 promotes cell glycolysis and proliferation in renal cell carcinoma

20 Jan 2022

Abstract excerpt

BACKGROUND: Cancer cells prefer utilizing aerobic glycolysis in order to exacerbate tumor mass and maintain un-regulated proliferative rates. As a key glycolytic activator, phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) has been implicated in multiple tumor type progression. However, the specific function and clinical significance of PFKFB3 in renal cell carcinoma (RCC) are yet not clarified. This...

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PMID: 35057732
DOI: 10.1186/s12885-022-09183-2

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