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Article

Functional linkage of adenine nucleotide binding sites in mammalian muscle 6-phosphofructokinase.

The Journal of biological chemistry - 18 May 2012

Brüser Antje, Kirchberger Jürgen, Kloos Marco, Sträter Norbert, Schöneberg Torsten

Abstract excerpt

6-Phosphofructokinases (Pfk) are homo- and heterooligomeric, allosteric enzymes that catalyze one of the rate-limiting steps of the glycolysis: the phosphorylation of fructose 6-phosphate at position 1. Pfk activity is modulated by a number of regulators including adenine nucleotides. Recent crystal structures from eukaryotic Pfk revealed several adenine nucleotide binding sites. Herein, we determined the...

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Identifiers

PMID: 22474333
DOI: 10.1074/jbc.M112.347153
PMCID: PMC3366854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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