Immune landscape, evolution, hypoxia-mediated viral mimicry pathways and therapeutic potential in molecular subtypes of pancreatic neuroendocrine tumours.

doi:10.1136/gutjnl-2020-321016

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Article

Immune landscape, evolution, hypoxia-mediated viral mimicry pathways and therapeutic potential in molecular subtypes of pancreatic neuroendocrine tumours.

Gut - 1 Oct 2021

Young Kate, Lawlor Rita T, Ragulan Chanthirika, Patil Yatish, Mafficini Andrea, Bersani Samantha, Antonello Davide, Mansfield David, Cingarlini Sara, Landoni Luca, Pea Antonio, Luchini Claudio, Piredda Liliana, Kannan Nagarajan, Nyamundanda Gift, Morganstein Daniel, Chau Ian, Wiedenmann Bertram, Milella Michele, Melcher Alan, Cunningham David, Starling Naureen, Scarpa Aldo, Sadanandam Anguraj

Abstract excerpt

OBJECTIVE: A comprehensive analysis of the immune landscape of pancreatic neuroendocrine tumours (PanNETs) was performed according to clinicopathological parameters and previously defined molecular subtypes to identify potential therapeutic vulnerabilities in this disease. DESIGN: Differential expression analysis of 600 immune-related genes was performed on 207 PanNET samples, comprising a training cohort (n=72)...

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Identifiers

PMID: 32883872
DOI: 10.1136/gutjnl-2020-321016
PMCID: PMC8458094

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