Article

Multi-Omics Profiling Reveals the Interplay Between Genomic Instability and Microenvironmental Remodeling in Pancreatic Neuroendocrine Tumors

2025-09-03

Abstract excerpt

Pancreatic neuroendocrine tumors (PNETs) represent a biologically heterogeneous group of neoplasms shaped by both intrinsic genomic alterations and dynamic interactions with the tumor microenvironment (TME). Conventional analytical approaches offered limited insight into these complex mechanisms. However, the emergence of multi-omics technologies including genomics, transcriptomics, proteomics, and spatial single-...

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Literature Corpus work: 60b6ef46-3f49-55e8-8c6b-013ef264a0cf
DOI: 10.20944/preprints202509.0362.v1

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