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Article

A metabolite binding protein moonlights as a bile-responsive chaperone.

The EMBO journal - 15 Oct 2020

Lee Changhan, Betschinger Patrick, Wu Kevin, Żyła Dawid S, Glockshuber Rudi, Bardwell James Ca

Abstract excerpt

Bile salts are secreted into the gastrointestinal tract to aid in the absorption of lipids. In addition, bile salts show potent antimicrobial activity in part by mediating bacterial protein unfolding and aggregation. Here, using a protein folding sensor, we made the surprising discovery that the Escherichia coli periplasmic glycerol-3-phosphate (G3P)-binding protein UgpB can serve, in the absence of its...

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Identifiers

PMID: 32882062
DOI: 10.15252/embj.2019104231
PMCID: PMC7560199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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