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Article

Complete alanine scanning of the Escherichia coli RbsB ribose binding protein reveals residues important for chemoreceptor signaling and periplasmic abundance.

Scientific reports - 15 Aug 2017

Reimer Artur, Maffenbeier Vitali, Dubey Manupriyam, Sentchilo Vladimir, Tavares Diogo, Gil Manuel Hernandez, Beggah Siham, van der Meer Jan Roelof

Abstract excerpt

The Escherichia coli RbsB ribose binding protein has been used as a scaffold for predicting new ligand binding functions through in silico modeling, yet with limited success and reproducibility. In order to possibly improve the success of predictive modeling on RbsB, we study here the influence of individual residues on RbsB-mediated signaling in a near complete library of alanine-substituted RbsB mutants. Among...

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Source

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Identifiers

PMID: 28811596
DOI: 10.1038/s41598-017-08035-5
PMCID: PMC5557919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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