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Prokaryotic Substrate-Binding Proteins as Targets for Antimicrobial Therapies

1 Aug 2012

Abstract excerpt

The rapid emergence of multidrug-resistant bacteria over the last two decades has catalyzed a shift away from traditional antibiotic development strategies and encouraged the search for unconventional drug targets. Prokaryotic substrate- binding proteins (SBPs), together with their cognate ATP-binding cassette (ABC) transporters, facilitate the unidirectional, transbilayer movement of specific extracytosolic...

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PMID: 22664093
DOI: 10.2174/138945012803530170

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