Article

Extracellular loops of the β-barrel domain catalyze rapid folding for function of self-associating autotransporters

2025-04-08

Abstract excerpt

Bacterial aggregation is a phenotype associated with disease pathogenesis. Aggregate formation enhances biofilm development, host colonization, and resistance to antibiotics and host defenses. Antigen 43 (Ag43) is a surface-located autotransporter produced by pathogenic Escherichia coli that mediates cell aggregation in biofilms. Two Ag43 molecules, each from neighboring bacterial cells, fold into elongated β-hel...

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Literature Corpus work: b8c2e46d-0716-5b75-b53b-4e9301bd051b
DOI: 10.1101/2025.04.08.647479

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