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Article

Exploration of CTNNB1 ctDNA as a putative biomarker for hepatoblastoma.

Pediatric blood & cancer - 1 Nov 2020

Kahana-Edwin Smadar, McCowage Geoffrey, Cain Lucy, Saletta Federica, Yuksel Aysen, Graf Nicole, Karpelowsky Jonathan

Abstract excerpt

Driver mutations in the CTNNB1 gene (encoding β-catenin) are a hallmark of sporadic hepatoblastoma (HBL). Our results show that CTNNB1 circulating tumour DNA (ctDNA) is readily detected in patients diagnosed with localised HBL, with serial sampling along the course of therapy and follow up providing a sensitive mechanism to monitor tumour dynamics and response to treatment. This exciting potential for CTNNB1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 32881242
DOI: 10.1002/pbc.28594

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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