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Article

Chiral discrimination in a mutated IDH enzymatic reaction in cancer: a computational perspective.

European biophysics journal : EBJ - 1 Oct 2020

Thamim Masthan, Thirumoorthy Krishnan

Abstract excerpt

Chiral discrimination in biological systems, such as L-amino acids in proteins and d-sugars in nucleic acids, has been proposed to depend on various mechanisms, and chiral discrimination by mutated enzymes mediating cancer cell signaling is important in current research. We have explored how mutated isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate which in...

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PMID: 32880665
DOI: 10.1007/s00249-020-01460-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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