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Article

Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes.

Journal of the American Chemical Society - 27 Jan 2016

Walker Olivia S, Elsässer Simon J, Mahesh Mohan, Bachman Martin, Balasubramanian Shankar, Chin Jason W

Abstract excerpt

Isocitrate dehydrogenase is mutated at a key active site arginine residue (Arg172 in IDH2) in many cancers, leading to the synthesis of the oncometabolite (R)-2-hydroxyglutarate (2HG). To investigate the early events following acquisition of this mutation in mammalian cells we created a photoactivatable version of IDH2(R172K), in which K172 is replaced with a photocaged lysine (PCK), via genetic code expansion....

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Identifiers

PMID: 26761588
DOI: 10.1021/jacs.5b07627
PMCID: PMC4821487

Genes

IDH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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