Article

Discovery of Chirally-dependent Protein O-2-Hydroxyglutarylation by D2HG and L2HG

2025-01-27

Abstract excerpt

Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are common in multiple types of human cancer, leading to the accumulation of D-2-hydroxyglutarate (D2HG) and the promotion of tumorigenesis 1 . Here we discovered a novel O -2- hydroxyglutarylation by D2HG using chemical proteomics and further revealed distinct chiral preferences for D/L2HG modifications. Notably, we identified two kinases, MRCKA and SLK, m...

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Literature Corpus work: a4164e69-6fa9-5477-aa44-741a7bee4838
DOI: 10.1101/2025.01.24.634716

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