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Article

Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism.

Biochemistry - 2 Jul 2013

Rendina Alan R, Pietrak Beth, Smallwood Angela, Zhao Huizhen, Qi Hongwei, Quinn Chad, Adams Nicholas D, Concha Nestor, Duraiswami Chaya, Thrall Sara H, Sweitzer Sharon, Schwartz Benjamin

Abstract excerpt

The human, cytosolic enzyme isocitrate dehydrogenase 1 (IDH1) reversibly converts isocitrate to α-ketoglutarate (αKG). Cancer-associated somatic mutations in IDH1 result in a loss of this normal function but a gain in a new or neomorphic ability to convert αKG to the oncometabolite 2-hydroxyglutarate (2HG). To improve our understanding of the basis for this phenomenon, we have conducted a detailed kinetic study...

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Source

Identifiers

PMID: 23731180
DOI: 10.1021/bi400514k

Genes

IDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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