Article
Mutations in ATM, NBN and BRCA2 predispose to aggressive prostate cancer in Poland.
International journal of cancer - 15 Nov 2020
Wokołorczyk Dominika, Kluźniak Wojciech, Huzarski Tomasz, Gronwald Jacek, Szymiczek Agata, Rusak Bogna, Stempa Klaudia, Gliniewicz Katarzyna, Kashyap Aniruddh, Morawska Sylwia, Dębniak Tadeusz, Jakubowska Anna, Szwiec Marek, Domagała Paweł, Lubiński Jan, Narod Steven A, Akbari Mohammad R, Cybulski Cezary
Abstract excerpt
In designing national strategies for genetic testing, it is important to define the full spectrum of pathogenic mutations in prostate cancer (PCa) susceptibility genes. To investigate the frequency of mutations in PCa susceptibility genes in Polish familial PCa cases and to estimate gene-related PCa risks and probability of aggressive disease, we analyzed the coding regions of 14 genes by exome sequencing in 390...
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