Article
Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function.
Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 2020
Zhong Xue, Su Lijing, Yang Yi, Nair-Gill Evan, Tang Miao, Anderton Priscilla, Li Xiaohong, Wang Jianhui, Zhan Xiaoming, Tomchick Diana R, Brautigam Chad A, Moresco Eva Marie Y, Choi Jin Huk, Beutler Bruce
Abstract excerpt
The small GTPase RABL3 is an oncogene of unknown physiological function. Homozygous knockout alleles of mouse Rabl3 were embryonic lethal, but a viable hypomorphic allele (xiamen [xm]) causing in-frame deletion of four amino acids from the interswitch region resulted in profound defects in lymphopoiesis. Impaired lymphoid progenitor development led to deficiencies of B cells, T cells, and natural killer (NK)...
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