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Article

Steroid treatment promotes an M2 anti-inflammatory macrophage phenotype in childhood lupus nephritis.

Pediatric nephrology (Berlin, Germany) - 1 Feb 2021

Ikezumi Yohei, Kondoh Tomomi, Matsumoto Yuji, Kumagai Naonori, Kaneko Masahiro, Hasegawa Hiroya, Yamada Takeshi, Kaneko Utako, Nikolic-Paterson David J

Abstract excerpt

BACKGROUND: M1-type proinflammatory macrophages (MΦ) promote glomerular injury in lupus nephritis (LN). However, whether this phenotype is altered by steroid therapy is unclear. Therefore, we investigated the effect of steroid treatment on MΦ phenotype in LN. METHODS: Patients with LN (7-18 years old) were divided into 2 groups: those with no treatment (N) before biopsy (n = 17) and those who underwent steroid...

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PMID: 32870362
DOI: 10.1007/s00467-020-04734-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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