Article
M2 macrophage is the predominant phenotype in airways inflammatory lesions in patients with granulomatosis with polyangiitis.
Arthritis research & therapy - 18 May 2017
de Souza Alexandre Wagner Silva, van Timmeren Mirjan, Sanders Jan-Stephan, Stegeman Coen, Heeringa Peter, Kallenberg Cees G M, Westra Johanna
Abstract excerpt
BACKGROUND: Macrophages may present two distinct phenotypes indicated as M1 and M2 under different stimuli. M1 and M2 macrophages have divergent functions that range from enhancement of inflammation for M1 to tissue repair and remodeling for M2 macrophages. The objective of this study was to evaluate the distribution of M1 and M2 macrophage phenotypes in biopsies from the airways of patients with active...
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