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Molecular biology of hepatitis B virus infection

7 Mar 2015

Abstract excerpt

Human hepatitis B virus (HBV) is the prototype of a family of small DNA viruses that productively infect hepatocytes, the major cell of the liver, and replicate by reverse transcription of a terminally redundant viral RNA, the pregenome. Upon infection, the circular, partially double-stranded virion DNA is converted in the nucleus to a covalently closed circular DNA (cccDNA) that assembles into a minichromosome,...

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PMID: 25759099
DOI: 10.1016/j.virol.2015.02.031

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