Article
Reassessment of p53 immunohistochemistry thresholds in invasive high grade bladder cancer shows a better correlation with TP53 and FGFR3 mutations.
Pathology, research and practice - 1 Nov 2020
Hodgson Anjelica, van Rhijn Bas W G, Kim Sung Sun, Ding Colleen, Saleeb Rola, Vesprini Danny, Liu Stanley K, Yousef George M, van der Kwast Theodorus H, Xu Bin, Downes Michelle R
Abstract excerpt
FGFR3 mutations are frequently mutually exclusive of TP53 mutations in invasive high grade urothelial carcinoma (HGUC) and p53 immunohistochemistry is often used as a surrogate for TP53 mutations. A 10 % staining cut off has been used in HGUC for designation as p53 positive or negative however, a novel contemporary method we have previously proposed (0% or >50 % - abnormal vs. 1-49 % - wild type) has shown...
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