Integrating Molecular Classification Based on FGFR3, KRAS, HRAS, and TP53 Mutation With TNM Staging Modestly Improves Prediction of Prognosis of Upper Tract Urothelial Carcinoma After Surgery.

doi:10.1111/iju.70620

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Integrating Molecular Classification Based on FGFR3, KRAS, HRAS, and TP53 Mutation With TNM Staging Modestly Improves Prediction of Prognosis of Upper Tract Urothelial Carcinoma After Surgery.

International journal of urology : official journal of the Japanese Urological Association - 1 Sept 2026

Yanagida Kazuki, Takada Ichiro, Ishida Tsuyoshi, Takei Kazuki, Kishitani Kenjiro, Minagawa Hideyuki, Kawai Taketo, Kaneko Tomoyuki, Sasajima Yuko, Nakagawa Tohru

Abstract excerpt

PURPOSE: To evaluate whether a simplified mutation-based classification using archival formalin-fixed paraffin-embedded (FFPE) specimens provides prognostic information beyond pathological stage in patients with upper tract urothelial carcinoma (UTUC) undergoing nephroureterectomy. MATERIALS AND METHODS: We retrospectively identified 107 UTUC patients who underwent nephroureterectomy between 2005 and 2020. DNA...

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