Article
Precore and basal core promoter mutations in Asian American patients with hepatitis B e antigen-positive chronic hepatitis B.
Alimentary pharmacology & therapeutics - 1 Feb 2013
Vutien P, Trinh H N, Nguyen K, Garcia R T, Nguyen H A, Levitt B S, Nguyen L, Ha N B, Ahmed A, Daugherty T, Garcia G, Nguyen M H
Abstract excerpt
BACKGROUND: Prior studies have shown that precore mutations abolish and basal core promoter (BCP) mutations down-regulate hepatitis B e antigen (HBeAg) production. Thus, the presence of precore and BCP mutations in HBeAg-positive patients indicates an infection with a mixed viral population of wild-type and precore and/or BCP mutant hepatitis B virus (HBV). To date, there has been limited study of the prevalence...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.