Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

13 Jun 2018

Abstract excerpt

Diminished growth factor signaling improves longevity in laboratory models, while a reduction in the somatotropic axis is favorably linked to human aging and longevity. Given the conserved role of this pathway on lifespan, therapeutic strategies, such as insulin-like growth factor-1 receptor (IGF-1R) monoclonal antibodies (mAb), represent a promising translational tool to target human aging. To this end, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dietary Effects on Health
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Spaceflight effects on biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29921922
DOI: 10.1038/s41467-018-04805-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female micePMID 29921922Read ↗

17α-Estradiol Modulates IGF1 and Hepatic Gene Expression in a Sex-Specific MannerSemantic proximity Read ↗

Control of aging and longevity by IGF-I signalingSemantic proximity Read ↗

IGF type 1 receptor: a cell cycle progression factor that regulates aging.Semantic proximity Read ↗

Healthspan and longevity can be extended by suppression of growth hormone signalingSemantic proximity Read ↗

Extending lifespan by modulating the growth hormone/insulin-like growth factor-1 axis: coming of ageSemantic proximity Read ↗

The insulin/IGF-1 signaling in mammals and its relevance to human longevity.Semantic proximity Read ↗

Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals.Semantic proximity Read ↗

Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levelsSemantic proximity Read ↗

Somatotropic Signaling: Trade-Offs Between Growth, Reproductive Development, and LongevitySemantic proximity Read ↗

Pleiotropic effects of growth hormone signaling in aging.Semantic proximity Read ↗

Low insulin‐like growth factor‐1 level predicts survival in humans with exceptional longevitySemantic proximity Read ↗

Diverse Roles of Growth Hormone and Insulin-Like Growth Factor-1 in Mammalian Aging: Progress and ControversiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.