Article
Glioma-derived mutations in IDH: from mechanism to potential therapy.
Biochemical and biophysical research communications - 25 Jun 2010
Fu Yuejun, Huang Rui, Du Jun, Yang Renjia, An Na, Liang Aihua
Abstract excerpt
Heterozygous mutations in either the R132 residue of isocitrate dehydrogenase I (IDH1) or the R172 residue of IDH2 in human gliomas were recently highlighted. Heterozygous mutations in the IDH1 occur in the majority of grade II and grade III gliomas and secondary glioblastomas and change the structure of the enzyme, which diminishes its ability to convert isocitrate (ICT) to alpha-ketoglutarate (alpha-KG) and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.