Article
Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.
The European journal of neuroscience - 1 Dec 2016
Hessel Ellen V S, van Lith Hein A, Wolterink-Donselaar Inge G, de Wit Marina, Groot Koerkamp Marian J A, Holstege Frank C P, Kas Martien J H, Fernandes Cathy, de Graan Pierre N E
Abstract excerpt
Febrile seizures (FS) are the most common seizure type in children. Recurrent FS are a risk factor for developing temporal lobe epilepsy later in life and are known to have a strong genetic component. Experimental FS (eFS) can be elicited in mice by warm-air induced hyperthermia. We used this model to screen the chromosome substitution strain (CSS) panel derived from C57BL/6J and A/J for FS susceptibility and...
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