Genetic and environmental interactions determine seizure susceptibility in epileptic EL mice.

doi:10.1111/j.1601-183X.2006.00204.x

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Article

Genetic and environmental interactions determine seizure susceptibility in epileptic EL mice.

Genes, brain, and behavior - 1 Oct 2006

Todorova M T, Mantis J G, Le M, Kim C Y, Seyfried T N

Abstract excerpt

Gene identification has progressed rapidly for monogenic epilepsies, but complex gene-environmental interactions have hindered progress in gene identification for multifactorial epilepsies. We analyzed the role of environmental risk factors in the inheritance of multifactorial idiopathic generalized epilepsy in the EL mouse. Seizure susceptibility was evaluated in the EL (E) and seizure-resistant ABP/LeJ (A)...

Topics

Age Factors
Animals
Chromosome Mapping
DNA
Disease Models, Animal
Environment
Epilepsy
Female
Genetic Predisposition to Disease
Genetics, Behavioral
Handling, Psychological
Lod Score
Male
Mice
Mice, Inbred Strains
Quantitative Trait Loci
Risk Factors
Seizures

Source

Open in PubMed

Identifiers

PMID: 17010098
DOI: 10.1111/j.1601-183X.2006.00204.x

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