Article
Genetic and environmental interactions determine seizure susceptibility in epileptic EL mice.
Genes, brain, and behavior - 1 Oct 2006
Todorova M T, Mantis J G, Le M, Kim C Y, Seyfried T N
Abstract excerpt
Gene identification has progressed rapidly for monogenic epilepsies, but complex gene-environmental interactions have hindered progress in gene identification for multifactorial epilepsies. We analyzed the role of environmental risk factors in the inheritance of multifactorial idiopathic generalized epilepsy in the EL mouse. Seizure susceptibility was evaluated in the EL (E) and seizure-resistant ABP/LeJ (A)...
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