A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

Abstract excerpt

Eukaryotes have evolved various quality control mechanisms to promote proteostasis in the endoplasmic reticulum (ER). Selective removal of certain ER domains via autophagy (termed as ER-phagy) has emerged as a major quality control mechanism. However, the degree to which ER-phagy is employed by other branches of ER-quality control remains largely elusive. Here, we identify a cytosolic protein, C53, that is...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autophagy in Disease and Therapy
• Share to Calcium signaling and nucleotide metabolism
• Share to Endoplasmic Reticulum Stress and Disease