Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy

10 Feb 2023

Abstract excerpt

UFMylation involves the covalent modification of substrate proteins with UFM1 (Ubiquitin-fold modifier 1) and is important for maintaining ER homeostasis. Stalled translation triggers the UFMylation of ER-bound ribosomes and activates C53-mediated autophagy to clear toxic polypeptides. C53 contains noncanonical shuffled ATG8-interacting motifs (sAIMs) that are essential for ATG8 interaction and autophagy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cancer-related gene regulation
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36762703
DOI: 10.15252/embj.2022112053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagyPMID 36762703Read ↗

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stressSemantic proximity Read ↗

A guide to UFMylation, an emerging posttranslational modificationSemantic proximity Read ↗

The Post-Translational Role of UFMylation in Physiology and DiseaseSemantic proximity Read ↗

ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and ReceptorsSemantic proximity Read ↗

ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and ReceptorsSemantic proximity Read ↗

ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological ProcessesSemantic proximity Read ↗

Ubiquitin-Like Modifiers: Emerging Regulators of Protozoan ParasitesSemantic proximity Read ↗

A UFD1 variant encoding a microprotein modulates UFD1f and IPMK ubiquitination to play pivotal roles in anti-stress responsesSemantic proximity Read ↗

SQSTM1/p62 UFMylation Enhances Autophagic Clearance of Pathogenic Mutant Huntingtin.Semantic proximity Read ↗

A Concerted Action of UBA5 C-Terminal Unstructured Regions Is Important for Transfer of Activated UFM1 to UFC1.Semantic proximity Read ↗

ATG8 delipidation is not universally critical for autophagy in plantsSemantic proximity Read ↗

Csn5 inhibits autophagy by regulating the ubiquitination of Atg6 and Tor to mediate the pathogenicity of Magnaporthe oryzaeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.