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Article

MPSR1 is a cytoplasmic PQC E3 ligase for eliminating emergent misfolded proteins in Arabidopsis thaliana.

Proceedings of the National Academy of Sciences of the United States of America - 14 Nov 2017

Kim Jong Hum, Cho Seok Keun, Oh Tae Rin, Ryu Moon Young, Yang Seong Wook, Kim Woo Taek

Abstract excerpt

Ubiquitin E3 ligases are crucial for eliminating misfolded proteins before they form cytotoxic aggregates that threaten cell fitness and survival. However, it remains unclear how emerging misfolded proteins in the cytoplasm can be selectively recognized and eliminated by E3 ligases in plants. We found that Misfolded Protein Sensing RING E3 ligase 1 (MPSR1) is an indispensable E3 ligase required for plant survival...

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PMID: 29087340
DOI: 10.1073/pnas.1713574114
PMCID: PMC5699081

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